Long-term data on tacrolimus treatment in lupus nephritis
نویسندگان
چکیده
منابع مشابه
Long-term data on corticosteroids and mycophenolate mofetil treatment in lupus nephritis.
OBJECTIVE We investigated the long-term outcome of patients with proliferative LN treated with CSs and MMF. METHODS This was a single-centre retrospective study on patients with biopsy-proven class III/IV ± V LN treated with prednisolone and MMF continuously as both early and maintenance immunosuppression. RESULTS Sixty-five patients were included, and followed for 91.9 (47.7) months. All r...
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BACKGROUND Combination therapy with cytotoxic drugs and corticosteroids reduces the risk for renal failure in patients with proliferative lupus nephritis (PLN), but uncertainty remains about the best mode of immunosuppression and its long-term effects. We report long-term results of combined azathioprine-prednisolone treatment for PLN, which has been the therapy of choice for the treatment of P...
متن کاملCarotid plaques in patients with long-term lupus nephritis.
OBJECTIVES To evaluate the prevalence of carotid plaques in patients with long-term lupus nephritis (LN). METHODS Intima-media thickness (IMT) and carotid plaques were evaluated with ultrasound in 75 patients after a follow-up of LN of 158+/-106 months and in 75 sex -and age-matched controls. Traditional and non-traditional atherosclerotic risks factors were also tested. RESULTS IMT was not...
متن کاملPharmacokinetics of orally administered tacrolimus in lupus nephritis patients.
The pharmacokinetics of orally administered tacrolimus were examined in six female lupus nephritis patients (mean age 43 years, range 24-55 years). Tacrolimus (3 mg) was administered after supper, and blood tacrolimus concentrations were measured just prior to dosing and 1, 2, 4, 6, 8, 12 and 24 h after administration. The maximum blood concentration (C(max)) was observed 4-8 h (mean: 6.7 h) af...
متن کاملTAC-TIC use of tacrolimus-based regimens in lupus nephritis
Current guidelines do not mention tacrolimus (TAC) as a treatment option and no consensus has been reported on the role of TAC in lupus nephritis (LN). The present study aimed to guide clinical judgement on the use of TAC in patients with LN. A meta-analysis was performed for clinical studies investigating TAC regimens in LN on the basis of treatment target (induction or maintenance), concomita...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2014
ISSN: 1462-0332,1462-0324
DOI: 10.1093/rheumatology/keu265